In 2003, she was again nominated in the same category for Mystic River.
Harden guest-starred as FBI undercover agent Dana Lewis posing as a white supremacist in 'Raw', an episode of the popular crime drama Law & Order: Special Victims Unit. In 2007, this role earned Harden her first Emmy Award nomination for best guest actress in a drama series. She reprised the role in the series' eighth-season premiere and again in the 12th-season episode 'Penetration' as a rape victim (aired November 10, 2010). In 2007, Harden appeared in several films, including Sean Penn's Into the Wild and Frank Darabont's The Mist (opposite Thomas Jane and Laurie Holden), based on the novella by Stephen King. Also in 2007, she shared top billing with Kevin Bacon in Rails & Ties, the directorial debut of Alison Eastwood.
In 2008, Harden appeared in Home playing a woman who has had a mastectomy.
